Deciphering Empty-Full Characterization: A Comparative Analysis of Available Analytical Methods

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Empty full ratio of AAV particles in a gene therapy drug is an important critical quality attribute. Due to the complexity of biological production process specifically, viral vector production mechanisms, AAV particles are quite heterogeneous. Purification process can’t entirely separate empty, partial and full particles from the process and hence a significant amount of empty and partial particles gets retained in the final product, potentially compromising quality of the product and raising safety concerns. The complexity of the challenge is understandable as the as gene therapy drugs contain multimeric protein assembly enclosing a genetic material. Where the actual process of DNA packaging remains loosely understood. There are various analytical technologies available for the characterization of these particles but almost every technology has some limitations, either in terms of the sample requirement, quality of information, precision, affordability, complexity of the assay or for their suitability in the GMP environment. AUC maintains its central role in this process and remains as a gold standard but at the same time has limited applicability across various phases of drug development due to its limited throughput and high sample requirements. There are various alternative technologies coming into play, including DLS, CDMS and Mass spectrometry, mass photometry and others. In this webinar we will discuss opportunities and challenges in various analytical technologies in characterizing this critical quality attribute of AAV vector for gene therapy.

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15:00 - 16:00 hs GMT+1

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Lun 27 de Febrero de 2025

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15:00 - 16:00 hs GMT+1

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Fecha

Lun 27-Feb-2025, 15:00 - 16:00 hs GMT+1

Descripción

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Mar 28 de Febrero de 2025

Mié 29 de Febrero de 2025

Jue 30 de Febrero de 2025

Vie 31 de Febrero de 2025

Sáb 01 de Febrero de 2025

Dom 02 de Febrero de 2025

Lun 03 de Febrero de 2025

Deciphering Empty-Full Characterization: A Comparative Analysis of Available Analytical Methods

15:00 - 16:00 hs GMT+1

Deciphering Empty-Full Characterization: A Comparative Analysis of Available Analytical Methods

Fecha

Lun 3-Feb-2025, 15:00 - 16:00 hs GMT+1

Descripción

Empty full ratio of AAV particles in a gene therapy drug is an important critical quality attribute. Due to the complexity of biological production process specifically, viral vector production mechanisms, AAV particles are quite heterogeneous. Purification process can’t entirely separate (...)

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Mar 04 de Febrero de 2025

Mié 05 de Febrero de 2025

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05:00 - 06:00 hs GMT+1

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Mié 5-Feb-2025, 05:00 - 06:00 hs GMT+1

Descripción

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16:00 - 17:00 hs GMT+1

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15:00 - 16:00 hs GMT+1

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16:00 - 17:00 hs GMT+1

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Vie 07 de Febrero de 2025

Sáb 08 de Febrero de 2025

Dom 09 de Febrero de 2025

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Mié 12 de Febrero de 2025

Jue 13 de Febrero de 2025

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05:00 - 06:00 hs GMT+1

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10:00 - 11:00 hs GMT+1

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Jue 13-Feb-2025, 10:00 - 11:00 hs GMT+1

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Love and Cybersecurity: Fostering a Culture of Security Awareness

20:00 - 21:00 hs GMT+1

Love and Cybersecurity: Fostering a Culture of Security Awareness

Fecha

Jue 13-Feb-2025, 20:00 - 21:00 hs GMT+1

Descripción

Join us this February, with a Valentine's Day twist, as we explore how to rekindle your passion for IT by embracing a culture of security awareness and appreciation. In this webinar, we'll discuss the importance of ditching the blame culture (...)

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Vie 14 de Febrero de 2025

Sáb 15 de Febrero de 2025

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Mié 19-Feb-2025, 16:00 - 17:00 hs GMT+1

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Mar 25-Feb-2025, 17:00 - 18:00 hs GMT+1

Descripción

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Mié 26-Feb-2025, 05:00 - 06:00 hs GMT+1

Descripción

n today’s relentless cybersecurity landscape, threats can still slip through undetected and compromise organizations, despite multiple security controls. In this webinar, Victor Sergeev and Amged Wageh, from Kaspersky, deep dive into real-world cases where compromise assessment became the last line (...)

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Jue 27 de Febrero de 2025

Navigating the Complexities of mRNA Therapies Analysis: Challenges, Techniques, and Quality Assessment Strategies

15:00 - 16:00 hs GMT+1

Navigating the Complexities of mRNA Therapies Analysis: Challenges, Techniques, and Quality Assessment Strategies

Fecha

Jue 27-Feb-2025, 15:00 - 16:00 hs GMT+1

Descripción

The approval and widespread adoption of mRNA vaccines have revolutionized the field of immunization, offering rapid and scalable solutions to combat infectious diseases. This success has spurred significant research into using mRNA for other therapies, including cell therapies, protein production, genome editing and protein replacement. (...)

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Deciphering Empty-Full Characterization: A Comparative Analysis of Available Analytical Methods - ERP Spain.com - España y América Latina

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